Mike Tyson vs. Jake Paul odds, prediction, props, date, rules: Nov. 15 fight card picks by best boxing expert

More than six months after they officially agreed to fight one another, Jake Paul vs. Mike Tyson will take place on Friday, November 15, when “The Baddest Man on the Planet” takes on a streamer who has turned himself into a boxer. Paul is 10-1 with seven knockouts, but he’s never faced someone with the resume of Tyson. However, Tyson is 58 years old and known by younger generations more for his acting than fighting, so will Tyson be able to keep up with the 27-year-old Paul?

The latest Jake Paul vs. Mike Tyson odds list Paul as the -330 favorite (risk $330 to win $100) to win, with Tyson a +250 underdog, with the over/under for total rounds at 5.5, with the Over priced at -150. The broadcast starts at 8 p.m. ET. Before making any Mike Tyson vs. Jake Paul picks, make sure you see the boxing predictions and betting advice from SportsLine combat expert Brandon Wise.  

Wise, who is the combat sports editor for CBS Sports, is an experienced boxing and mixed martial arts analyst who has consistently provided winning selections for SportsLine members. For the past four years, he has hit numerous boxing selections in big-time matchups.

For example, in March, Wise called a win in Round 1 for Paul (+200) against Ryan Bourland and also advised SportsLine members to take the Under 1.5 rounds (+120). Both bets connected when Paul scored a knockout towards the end of the first round. Anyone who has followed Wise’s combat sports picks has already seen massive returns.

Now, with the Paul vs. Tyson fight card approaching, Wise has studied the matchup from every angle and released confident picks for the fight. You can only see his picks and analysis at SportsLine. 

Mike Tyson vs. Jake Paul predictions  

Wise has analyzed the Jake Paul vs. Mike Tyson bout and is leaning Over 5.5 rounds at -150 odds. Tyson had to postpone this fight, which was originally scheduled for July, due to an ulcer flare-up, but that gave the 58-year-old more time to get into fighting shape. Videos emerging from Tyson’s camp don’t make it seem like Tyson is just showing up for the payday without caring of the results, he’s getting into his best shape in years.

Meanwhile, Paul has never been knocked out and although a loss to a 58-year-old fighter would damage his pursuit of being viewed as a legitimate boxer, being knocked out by someone approaching 60 would significantly harm his reputation. The 14-ounce gloves soften the damage of punches and given how seriously both fighters seem to be approaching this contest, Wise feels confident this will go Over. Six of Paul’s last eight fights have reached the sixth round, and none of those fighters have Tyson’s ring experience. See who to pick here. 

How to make Jake Paul vs. Mike Tyson picks

Wise has also locked in a confident money line pick and a method-of-victory prop bet that could pay out big. He’s only sharing his picks and analysis at SportsLine.

Who wins Mike Tyson vs. Jake Paul on November 15, and which Paul vs. Tyson props should you be all over? Visit SportsLine now to see Brandon Wise’s best bets for the July 20 bout, all from the CBS combat sports specialist who just called Paul’s first-round win in March, and find out.